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Oral semaglutide titrated to 14 mg daily reduced 3-point MACE by 14% in SOUL (HR 0.86, 95% CI 0.770.96), with the principal driver a 26% reduction in nonfatal MI

doi:10.1016/j.jff.2020.103819

Strategic Implications: New Treatment Needs: The influx of GLP-1 users with facial deflation, skin laxity, and rapid fat loss has accelerated demand for biostimulatory injectables (e.g., Sculptra), RF-based skin tightening, and regenerative modalities that support tissue rebuilding.5 Expanded Patient Segments: GLP-1 users represent a fast-growing cohort of "metabolically transformed" patients who require tailored onboarding, treatment education, and holistic planning that includes both corrective and preventive care.4 Cross-Specialty Collaboration: As endocrinologists and primary care physicians begin to encounter patients experiencing GLP-1-related aesthetic changes, the opportunity for referral partnerships and hybrid care models with aesthetic practitioners is growing rapidly.7 Predictive Diagnostics: From Reactive to Preventive Aesthetics As the aesthetic implications of GLP-1 therapies become more pronounced, the industry is shifting from reactive correction to proactive prevention

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