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For example, in the SELECT trial (17,600 patients with cardiovascular disease and obesity but without T2D), weekly subcutaneous Semaglutide (2.4 mg) reduced the risk of major adverse cardiovascular events (MACE heart attack, stroke, or cardiovascular death) by 20% compared to placebo (HR 0.80

A maintenance phase follows with a dose of 3 to 5 g per day

The pattern is consistent: patients with baseline nutrient deficiencies (common in calorie-restricted diets) show measurably better fat loss velocity when lipotropic support is added, while patients with adequate baseline status see minimal additional benefit

Age Range: Adult

continued improvement for chronic Weeks 8-12: Maximum benefit achieved