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The relevance of this observation extends to the wider family of GPCRs, with individual effects almost certainly receptor-specific, as both -arrestin-biased 54 and G protein-biased 55 ligands have proved effective for individual receptors in preclinical studies

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Beyond cellular senescence, FOXO4-DRI demonstrates promise in neuroprotection, muscle regeneration, and cardiovascular health, positioning it as a keystone compound in longevity medicine (5, 6, 7)

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