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doi:10.2164/jandrol.111.013961

Given that TSLP is considered the upstream initiator of the Th2 cascade in eczema, a peptide that specifically reduces its expression could interrupt the disease at its origin point rather than managing downstream consequences

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14 NAD + biosynthesis De novo pathway Mammalian cells can generate NAD + de novo from dietary tryptophan (Trp) by the kynurenine pathway (KP), which is initialized by either TDO or IDO