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doi: 10.1023/A:1022894303834

Desideri, E., F

In older animals, both high-dose paraxanthine and caffeine (CAF HIGH) produced the most significant improvements, consistent with previous research showing age-related declines in learning and memory acquisition in water maze tests (Shukitt-Hale et al

This level of accumulation was considered moderate showing sustained drug release over long dosing intervals

Recent studies based on machine learning identified different families of compounds already known to target SnCs, such as cardiac glycosides 38 or molecules mimicking the combination of dasatinib/quercetin 39 , confirming the real potential of this technique