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In GetGoal-Mono Japan, Japanese patients experienced a 0.74% and 0.99% reduction in HbA 1c (one-step or two-step dose increase, respectively) at week 24, which was sustained at week 76 (reduction of 0.72% across both groups) from a baseline HbA 1c of 66 mmol/mol (8.2%)

The SmPC notes that titration steps can be extended or the dose temporarily reduced to improve tolerability if needed

Side effects include bloating and nausea, with B12 shots available for relief

& Blouet, C

Simultaneously, long-chain acyl-CoA synthetase 4 (ACSL4) expression decreases, reducing the availability of oxidizable PUFAs, although the exact mechanism underlying this remains unclear