The number of records related to HTN and DM in Science Direct rose significantly from 1,453 in 2014 to 4,003 in 2024, indicating a growing interest in this topic within the scientific community
Additionally, it has been reported that OS affects epigenetic regulatory mechanisms involved in the regulation of pancreatic cell survival and insulin secretion, like DNA methylation, chromatin architectural modification, and non-coding RNA (Figure 3) that mitigate ROS without disrupting physiological redox signaling (Zaher and Stephens, 2025)
Multiple mechanistic pathways have been proposed in animal and cell studies
Exercise According to preliminary data, moderate exercise increases glutathione levels, according to a study published in 2020 in The Journal of the Federation of American Societies for Experimental Biology (FASEB) (13)
The decrease in waist circumference in the GlyNAC supplemented group suggests that the fat loss occurred preferentially in the abdomen