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These evidence-based treatments include nutritional counseling, hormonal balance, and advanced therapies like Semaglutide and Tirzepatide injections
In addition, mitochondrial calcium overload and dysfunction further trigger apoptosis via mitochondrial permeability transition pores (mPTP) opening and loss of mitochondrial membrane potential [242, 243]
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Notably, the nuclear E GSH , despite the nucleus being a membrane-bound compartment, is indistinguishable from that of the cytosol and remains remarkably stable throughout the cell cycle
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