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Preclinical evidence shows that 1,25(OH)2D induces a shift from inflammatory (M1) to reparative (M2) macrophages, promoting the secretion of hydrogen peroxide, a critical factor for M.tb clearance [17, 18]

A comprehensive literature search across multiple databases identified a total of 6,541 studies, retrieved from PubMed ( n = 848), Web of Science ( n = 1,015), Scopus ( n = 2,523), Embase ( n = 1,525), Cochrane ( n = 367), as well as Google Scholar and manual reference searches ( n = 263)

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