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Pharmacologically mediated, marked initial maternal body weight loss and reductions in body weight gain and food consumption coincided with the occurrence of sporadic abnormalities (vertebra, sternebra, ribs) at 0.075 mg/kg twice weekly (3X human exposure)

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The enzyme harbors a mononuclear Fe(II) center coordinated by His79, His135 and Asp154, together with three water molecules, resulting in an octahedral geometry

It is currently being studied at doses ranging from 1 mg to 12 mg per week in clinical trials

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