Prominent features of structural remodelling are atrial dilatation, atrial myocyte hypertrophy and fibrosis, which create a substrate for AF [119]
Surprisingly, the Sox2 proximal promoter stays methylation-free in differentiated ESC-derived glutamatergic neurons and in adult brain tissue (Meissner et al., 2008
The mechanism involves angiogenesis (new blood vessel formation) and upregulation of growth factor receptors at the injury site
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