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This starting dose serves primarily as a tolerability dose rather than a therapeutic dose, helping patients acclimate to the medication's effects on the gastrointestinal system

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The article says most healthcare providers recommend a moderate deficit of 300 to 500 calories below maintenance rather than aggressive 800 to 1,000 calorie cuts

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Furthermore, another study demonstrated that IL1 induces elevated IL-6 expression in human orbital fibroblasts (103)