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In summary, antiamyloid mAbs have an irreplaceable advantage in clearing existing deposits and are a synergistic and complementary approach to current treatments for ATTR-CM

Furthermore, the NICD can cooperate with transcription factors that target lipid metabolism genes through non-canonical interactions, thus modulating membrane synthesis and redox balance, which are crucial for the proliferation of CSCs

However, understanding how these medications work, potential considerations during treatment, and when to seek medical guidance ensures safe and effective use of both therapies together

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The presence or absence of DAC changes how the compound behaves biologically