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GLP-1 agonists were engineered to mimic a naturally occurring hormone that controls hunger, making them inherently more powerful for appetite regulation

Pharmacologic approaches to glycemic treatment: standards of medical care in Diabetes2020

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The widespread application of GLP-1 receptor agonists at the population level may impose significant financial pressure on pharmaceutical budgets, with modeling studies indicating that treating all eligible individuals with diabetes and obesity might need a 1020% rise in drug expenditures in several nations