Muscle cramps and weakness
Are there any risks or side effects
Elevated homocysteine level is associated with an increased risk for atherosclerotic and thrombotic events.45 Meta-analysis of 30 studies involving 5073 ischaemic heart disease (IHD) events suggested that elevated homocysteine level was at most a modest independent predictor of IHD and stroke risk in healthy populations, and a 25% reduction in homocysteine levels was associated with 11% and 19% reduction in IHD and stroke, respectively.46 Another meta-analysis also provided a strong evidence of the causal association between homocysteine and cardiovascular disease, and showed that lowering homocysteine level by 3 mol/L could reduce the risk of IHD by 16% and stroke by 24%.47 Vitamin B 12 , folic acid, and vitamin B 6 are required for homocysteine metabolism, and often nutritional deficiency of these vitamins can cause hyperhomocysteinaemia

Some research suggests that the inflammatory cascade triggered by chronically elevated homocysteine may lower the threshold for anxiety and depressive episodes in susceptible individuals
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