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46,47,48 In 2005, the discovery of pseudouridine () modification addressed the immunogenicity issue of in vitro-synthesized mRNA, 49 leading to the initiation of the first human trial of an mRNA vaccine against melanoma in 2008

TB500 (Thymosin Beta-4 fragment) is being researched for its involvement in cell migration, angiogenesis, and tissue regeneration

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[22] IL-10 and Treg cells promote balance (homeostasis), and self-tolerance and help prevent autoimmunity and allergies