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Preclinical Research: Fat Metabolism and Adiposity Initial animal studies conducted in the early 2000s reported that chronic exposure to AOD-9604 in obese mice and Zucker rats led to reductions in weight gain and increased fat oxidation

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At 24 h after administration, the mean concentrations of total radioactivity in the kidney, thymus, liver, spleen, and gastric wall decreased significantly but were still higher than the mean concentrations in the plasma at the same time

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