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A 2016 systematic review of clinical evidence on newer vs older diabetes medications supports metformin as 1st-line therapy for type 2 diabetes given its relative safety & beneficial effect to lower HbA1c, absence of weight gain, and reduced cardiovascular mortality (Maruthur et al, 2016)

Examples include insulin and glucagon

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AOD-9604 Trial Data (Efficacy, Adverse Events) AOD-9604 was studied across six randomized, double-blind, placebo-controlled trials involving roughly 900 participants between 2001 and 2006, making it one of the more extensively studied peptide fragments in human research