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Studies also found that increased expression of zinc transport protein 7 (ZIP7) in the heart, inhibition of PINK1/Parkin-mediated mitophagy, and exacerbation of cardiac insufficiency and fibrosis in mice were found in an HFD/STZ-induced mouse model, which was reversed by knockdown of ZIP7 [183]

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Disrupted Cacna1c gene expression perturbs spontaneous Ca(2+) activity causing abnormal brain development and increased anxiety