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Studies have also shown that heterozygosity in these loci, such as DRB1*03-DQB1*02/DRB1*0401-DQB1*0302, make it at least six times more likely to develop T1D compared to homozygosity for either haplotype (58, 60)

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In laboratory settings, it is the standard vehicle for reconstituting lyophilized peptides and proteins, ensuring that the chemical stability and pH environment remain optimal for in-vitro analysis without introducing bacterial contaminants that could degrade sensitive compounds