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Others, including the FDA and Eli Lilly, have argued that adding commonly available vitamins to avoid the "essentially a copy" restriction does not constitute a legitimate clinical modification

doi: 10.1111/j.1469-1809.2007.00398.x 6 Martnez-CortsGSalazar-FloresJGabriela Fernndez-RodrguezLRubi-CastellanosRRodrguez-LoyaCVelarde-FlixJSet al

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Zhou X, Liu Y, Wang X et al (2020) Effect of particle size on the cellular uptake and anti-inflammatory activity of oral nanotherapeutics

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