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This article shows that unimolecular GLP1/GIP co-agonism corrects obesity and glucose intolerance in obese rodents and non-human primates

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[Google Scholar] Lucki J, Rnby B

dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies

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