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Although, it is barely heard of in todays society it was one of the first diseases to be described by Hippocrates, 400BC

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Protein post-translational modifications regulated by butyrate Acetylation Lysine acetylation (Kac), a critical post-translational modification, involves the covalent attachment of acetyl groups to lysine residues, dynamically controlling protein functions, cellular signaling, and epigenetic states