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doi: 10.3389/fendo.2025.1562653 Received 17 January 2025 Accepted 31 March 2025 Published 17 April 2025 Volume 16 - 2025 Edited by Prem Prakash Kushwaha, Case Western Reserve University, United States Reviewed by Ankit Kushwaha, Stanford University, United States Saurabh Mishra, Cleveland Clinic, United States Updates Copyright 2025 Zong, Wang, Chen, Fang and Zhang

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A recent randomized and placebo-controlled study (2013) linked NAC supplements with hindered muscle performance and increased recovery time for several days after athletic exercise (Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise