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Two medications that have gained significant attention for their weight loss benefits are Mounjaro and Ozempic

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The report further distinguished clinical obesity, defined as excess adiposity with significant tissue or organ dysfunction that can lead to severe complications, from preclinical obesity, defined as excess adiposity without immediate organ dysfunction but with an increased risk of progression to clinical obesity and other non-communicable diseases

For comparison, the Wegovy trials reported nausea at approximately 44% and the Zepbound trials at approximately 28%

In 1987, researchers identified GLP-1 as a second incretin hormone derived from the transcription product of the proglucagon gene, which is cleaved differently depending on the tissue