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GLP-1 receptors are found in several brain regions, including: The ventral tegmental area (VTA) The nucleus accumbens The prefrontal cortex When activated by GLP-1, these receptors appear to reduce the release of dopamine in response to addictive substances

1a) involved in binding to the human GLP-1R (hGLP-1R) core and four of the six C-terminal residues (excepting Ala 25 to Thr and Val 33 to Leu) involved in binding to the hGLP-1R N-terminal domain are conserved in pGLP-1 26,27,28

We conduct GSA with Partial Rank Correlation Coefficient (PRCC), which is a global method where all input factors (model parameters and/or initial conditions) are varied simultaneously using latin hypercube sampling

Tirzepatide (a GLP-1/GIP dual agonist) and oral GLP-1 formulations activate slightly different receptor pathways and produce different gastrointestinal response patterns in some patients