In the SELECT trial, once weekly 2.4mg semaglutide led to a 20% reduction in MACE in non-diabetic, obese/overweight patients with established ASCVD
In my opinion, you should only consider surgery after giving rehabilitation a fair chance (at least 3-6 months) because it comes with a long recovery time, potential complications, and a very high cost
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doi: 10.1073/pnas.181330998 167 SchoneCApergis-SchouteJSakuraiTAdamantidisABurdakovD
The Numbers: Injectable tirzepatide: Nearly 100% bioavailability (all medication reaches bloodstream) Oral peptides without enhancement: Less than 1% bioavailability This means youd need 100 times more medication in oral form to match injection effectiveness Technical Barriers: Creating an oral version requires solving multiple problems: Protecting the peptide from stomach acid Preventing breakdown by digestive enzymes Getting the large molecule through intestinal walls Maintaining therapeutic drug levels Doing all this at a reasonable cost Current Development Status: Eli Lilly has not publicly announced advanced clinical trials for oral tirzepatide