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Incompetent valves result in blood pooling, which enlarges your vein and dilates
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Sinisgalli C, Faraone I, Vassallo A, Caddeo C, Bisaccia F, Armentano MF, et al
This neuro-vascular coupling enables astrocytes to adjust CBF in response to local neurons by eliciting vasoconstriction and vasodilation of brain vessels (22) regulating the contraction and dilation of pericytes surrounding capillaries
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