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In another study, a pug had a normal VHS value as high as 14.1, a bulldog as high as 14.4, and a Boston terrier as high as 13.1

Benedetti et al

It is believed that increasing PQQ concentrations may lead to a burst of reactive oxygen species (ROS), a reduction in ATP production, disruption of mitochondrial membrane potential (MMP), decreased production of the cytoprotective Bcl-2 protein, activation of caspase-3, and irregular MAPK phosphorylation patterns (Min et al., 2014b)

The compound exists in both reduced (GSH) and oxidized (GSSG) forms, with the reduced form being the active antioxidant state

Glucagon receptor activation may increase energy expenditure