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Furthermore, AZA (and its metabolites) can induce apoptosis of T cells through cluster of differentiation-28 (CD28) co-stimulation, mediated by a specific binding of azathioprine-generated 6-thioguanine triphosphate to Ras-related C3 botulinum toxin substrate 1 (Rac1) instead of GTP, converting a co-stimulatory into an apoptotic signal

There were two reports each of hyperpigmentation, cheilitis, sore throat, unspecified mood change, joint pain, fatigue, cold sores, and elevated liver enzyme levels (0.9%)

If palpitations are frequent or come with other symptoms, it is important to seek medical advice

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ZO-1 expression is suppressed by GM-CSF via miR-96/ERG in brain microvascular endothelial cells