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Advantages: no mixing required, concentration is pre-set and verified by pharmacy, less room for reconstitution errors

10.1001/jamanetworkopen.2024.34180 172 LeeJ.WestD.PellegriniC.WeiJ.WilcoxS.Neils-StrunjasJ.et al (2025)

Ida, T., Sawa, T., Ihara, H., Tsuchiya, Y., Watanabe, Y., Kumagai, Y

Fortunately, a recent change in the formulation has reduced the sulfur odor and skin irritability, allowing its use as a cream. Trial details The quasi-randomized, multicenter, evaluator-blinded clinical trial from Brazil was conducted between October 2019 and February 2020, involving 40 women representative of a Brazilian sample of melasma patients, all of whom had facial melasma with skin phototype II to V, and aged 30 to 55

The data distribution was assessed using Anderson-Darling, DAgostino & Person, Shapiro-Wilk, and Kolmogorov-Smirnov tests