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After analyzing nine different studies conducted on over 900 men and women, scientists concluded that carnitine promotes weight loss , but its effects decrease over time

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Currently, weight loss or weight-neutral antidiabetic drugs mainly include metformin, alpha-glucosidase inhibitors, GLP-1 receptor agonists (GLP-1RA), DPP-4 inhibitors, SGLT-2 inhibitors (SGLT-2i), and insulin analogs

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We also showed that inhibition of EPAC increased mitochondrial ROS production only in primary melanoma cells consistent with the role of EPAC-RAP1 signaling in maintaining mitochondrial integrity by suppressing mitochondrial ROS production and oxidative damage [5, 9]