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Unlike exogenous GH administration, GHRH analogs preserve the physiologic feedback loop, resulting in more natural GH pulsatility without the risks associated with supraphysiological GH levels [7]

Lilly's triple agonist delivered a mean 28.7% body weight reduction at 68 weeks on the 12 mg dose in TRIUMPH-4 - roughly 71 pounds for the average enrollee

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However, as discussed next, a bona fide indication for GLP-1 RAs to reduce the risk of developing HF or to treat chronic HF arguably requires the resolution of several unknowns