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Male BALB/c-nu nude mice aged 4 weeks and weighing 18 ~ 22 g were purchased from the Experimental Animal Centre of Southern Medical University (Guangzhou, China) and housed in a specific pathogen-free air-conditioned room (25 2 and 65% 5% humidity) with a 12-h light/dark cycle

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Short-term GH pulses and higher IGF-1 can enhance glucose uptake in muscle and fat, reduce fasting insulin requirements, and redirect substrate utilization toward improved metabolic flexibility

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A total of 26 male SD rats underwent the MCAO procedure to induce focal stroke