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Evaluation of sucrose laurate as an intestinal permeation enhancer for macromolecules: ex vivo and in vivo studies

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25 The Val 23 and Ile 27 used in tirzepatide are likely to have little impact on either GLP-1 or GIP activity because they are the same kind of residue and no specific interaction in these sites has been detected

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Readers should factor this evolving regulatory environment into any enrollment decision, regardless of which platform they are evaluating