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Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, constipation, and abdominal discomfort

31,32 SAM is an important metabolic substrate and is involved in the initiation of 3 major pathways: (1) transmethylation for the synthesis of various proteins and lipids, among them phospholipids for cell membranes

Funding This work was supported by the Key Project of Taizhou Science and Technology Bureau (24gyz01), the General Scientific Research Project of Zhejiang Provincial Education Department (Y202352110), and the Taizhou Science and Technology Plan (23gyb20)

Polypodium leucotomos extract (480 mg twice daily)

Spranger, S