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Modifications of physical and functional integrity of the blood-brain barrier in an inducible mouse model of neurodegeneration

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Besides, biologics have a high degree of specificity and affinity for therapeutic receptors owing to the extensive area of interaction with targets through established motifs, but they suffer from low cellular membrane permeability, poor oral bioavailability, and metabolic instability, resulting in limited intracellular applications [13, 14]

If freezing is required, single-use aliquots minimize structural stress and improve consistency

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