These findings are consistent with previous reports showing that exposed hydrophobic surfaces on amyloidogenic aggregates mediate aberrant interactions with essential cellular proteins, leading to their sequestration and functional impairment 81
Cells were spun at 4C for 20 min to pellet, and resuspended in lysis buffer (50 mM NaH2PO4, 300 mM NaCl, 10 mM imidazole, pH = 8)
[DOI] [PubMed] [Google Scholar] 61.Simionescu O, Dumitrescu D, Costache M, Blum A
In a rat model, sulforaphane, a known antioxidant, has been demonstrated to activate the cellular antioxidant pathway through the glutamate-cysteine ligase catalytic subunit and Nrf2, resulting in a reduction in memory impairment
PLoS One 11 , e0160486 (2016)