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Abstract Since the industrial revolution, the production, and consequently the emission of metals, has increased exponentially, overwhelming the natural cycles of metals in many ecosystems

Spitzoid melanoma on the leg of a boy aged 10 years an amelanotic, nodular lesion that lacks traditional ABCDE diagnostic criteria Figures 3B and 3C courtesy of Professor Pascale Guitera Pigmented epithelioid melanocytomas Pigmented epithelioid melanocytomas (PEMs) most commonly arise in children, adolescents and young adults