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GLP-1 medications work by slowing digestion and reducing appetite, powerful changes that can sometimes lead to side effects like nausea, fatigue, or digestive discomfort

These medications help many patients feel fuller longer, reduce cravings, and support gradual, sustainable weight loss when combined with lifestyle changes

There are some non-M1 and non-M2 restorative type macrophages, which have both anti-inflammation and anti-fibrogenic features, highly express matrix metalloproteinase (MMP), and have a LY6C low , F4/80 + phenotype (Kazankov et al., 2019)

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Future research should study further the interactions of these medications on long-term impacts on obesity