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A JAMA Network Open retrospective cohort study of 125,474 adults with overweight or obesity: Patients with T2DM: 46.5% discontinued by year one 64.1% discontinued by year two Patients without T2DM: 64.8% discontinued by year one 84.4% discontinued by year two Nearly 85% of patients without diabetes stopped taking GLP-1s within two years

While (static) structure is typically determined by Bragg scattering, diffuse scattering occurs when molecules move, and scattering occurs at positions away from the resting position

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At 0.25 mg (the starting dose), weight loss is minimal because the dose is designed for tolerability, not efficacy