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In the patient-level models, cumulative prescription count dominated the association with switching, supporting the concern that such models largely capture opportunity rather than clinical determinants

Signals for disease modification Evidence for true disease modification remains low-certainty and hypothesis-generating, with recent observational signals serving as a foundation for potential disease modification rather than established therapeutic benefit (100)

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This delayed digestion can create a sensation of fullness that persists during and after meals, which some patients initially interpret as fatigue

Any persistent or concerning changes in sexual function warrant proper medical evaluation to identify underlying causes