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This is the side effect that concerns doctors most, particularly for patients with existing cardiovascular conditions

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if cold sensitivity persists beyond 8 weeks or worsens despite lifestyle adjustments, your provider may recommend the Precision Peptide Genetic Test to identify whether specific genetic variants in temperature-regulation pathways are predisposing you to this side effect, allowing for more targeted compound selection or dosing

In addition, the cases of oral hyperpigmentation reported to date do not appear to be drug dose-dependent (Table 2)