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Thus, TB-500 is one of the active fragments of that protein

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In phase II trials for dermal applications, TB-500 has shown promising results in patients with pressure ulcers, stasis ulcers, and epidermolysis bullosa [7]

The findings suggest a new bacterial pathogenesis pathway in acne and provide one molecular explanation for a long-standing clinical observation that vitamin B 12 supplementation leads to acne development in a subset of individuals