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Nevertheless, pharmaceutical companies have pursued the twincretin concept, developing GLP-1/GIP dual agonists such as tirzepatide, an analogue biased in favour of GIP over GLP-1 activity [55], and NNC0090-2746, another analogue with balanced GLP-1 and GIP activity [56]

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Compliance with Ethics Guidelines This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors

OSA is also related to abnormal glucose metabolism in non-obese individuals, and the risk of OSA occurrence is higher in diabetes patients who require insulin treatment [64]

10 Additionally, not all OSA patients are obese and therefore wouldnt benefit from GLP-1s