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Description

We recently described the cell-penetrating peptide FOXO4-DRI as a senolytic drug 5

The cancer cells then enter a latent state as single cells or micrometastases

By inhibiting NNMT and preserving NAD, 5-Amino-1MQ indirectly boosts SIRT1 activity , leading to: Increased fat oxidation SIRT1 activates PGC-1 (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a master regulator of mitochondrial biogenesis and fat metabolism