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3 GLP-1RAs and NAFLD/NASH When dietary nutrients are ingested, endogenous incretins (GIP and GLP-1) activate K and L cells in the gut, which then secrete GIP and GLP-1

Kinetic parameters Steady-state kinetics constants were estimated with purified laccase variants for ABTS (Panreac, A1088), DMP (Merck, D135550), guaiacol (Thermo Scientific, 120192500) and sinapic acid (Apollo Scientific, BIS8112) in 100 mM sodium phosphatecitrate buffer pH 5.0 or 6.0

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