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Lancet Diabetes Endocrinol 2019;7:606-17.ArticlePubMed 45

demonstrated similar effects that were not suppressed by reserpine, propranolol, or phentolamine, thereby suggesting a direct mode of action [3234]

This approach works especially well for people who are sensitive to medications in general, those who have experienced significant nausea on semaglutide or tirzepatide , or anyone who prioritizes comfort during the initial adaptation period

If nausea persists or interferes with meals, consult a healthcare provider for possible dose adjustment