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It has been concluded that GLP-1RAs can improve cognitive performance and brain function, especially in the early stages of neurodegeneration and among groups at high risk of T2DM [33]

These improvements occur independently of the weight loss effects, suggesting direct metabolic benefits from the medication

The results from these trials were positive and eventually led to Wegovy receiving FDA approval as a chronic weight management medication in June 2021

Most patients (93%) tolerate side effects well enough to continue treatment

Reference standards under that designation serve analytical work, comparator use in research assays, and stability or impurity studies