For International Clinical Trials Day 2026, Angelini Pharma explores the role of First-in-Human trials and the elements that make this phase such a critical milestone in drug development
Results from this trial suggested that after 28 days of treatment, the setmelanotide group demonstrated a significant mean weight reduction of 3.48 kg from baseline, accompanied by a significant decrease in mean waist circumference of 5.83 cm
These data suggest that PGN can induce inflammation resulting in macrophage and neutrophil infiltration, and can also directly activate monocytes, furthering the inflammatory process
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Rather than recommending one treatment for everyone, our clinicians assess each patient individually, considering medical history, lifestyle, previous weight loss attempts and long-term health goals